Clinicopathological Study of Solitary Thyroid Nodule


  • Abdullah Al Mamun General Hospital, Narayanganj
  • Zahedul Alam National Institute of ENT, Tejgaon, Dhaka
  • Mazharul Islam Rangpur Medical College, Rangpur
  • Mashuque Mahamud National Institute of ENT, Tejgaon, Dhaka
  • Mohammad Ashaduzzaman Colonel Malek Medical College, Manikganj
  • Md Shaiful Azam Colonel Malek Medical College, Manikganj
  • G H M Shahidul Haque Colonel Malek Medical College, Manikganj



Solitary thyroid nodule, papillary carcinoma, follicular carcinoma, medullary carcinoma


To find out the incidence of malignancy in patient with solitary thyroid nodule, this cross-sectional study was carried out in Otolaryngology & Head-Neck Surgery department of Sir Salimullah Medical College & Mitford Hospital (SSMC & MH) and Bangabondhu Sheikh Mujib Medical University (BSMMU), Dhaka; from July 2012 to December 2013. In this study mean age of the subjects was 35.6 ± 13.54 years and the highest frequency (38%) was within 21-30 years with female predominance (78%). Thyroid swelling was the common presentation in all (100%) cases. Some patients also presented with other symptoms like cervical lymphadenopathy (13%), dysphagia (1%), dyspnoea (1%), hoarseness of voice (1%). In this study, solitary thyroid nodules constituted 73% firm, 6% hard and 11% cystic. Malignancy rate (72.22%) was higher in firm nodule. Functional status of nodules was categorized by isotope scanning of the thyroid gland, which showed (96%) cold, (4%) warm and no any hot nodules. In the study out of 96 cold nodular goiters, 18.75 % were malignant and out of 89 solid nodule 80.89% were benign and 19.10% malignant, also out of 11 cystic nodules 90.9% were benign and 9.1% malignant. It is noticeable in the study that malignancy is significantly higher (p<0.001) in solid than cystic nodule. Histopathological findings showed, among the subjects, 54% were nodular goiter and 2 % thyroiditis in non-neoplastic lesion, and in neoplastic lesion 26% was benign (follicular adenoma) and 18% malignant. Among the malignants, 83.33% were papillary carcinoma, 11.11% follicular carcinoma and 5.55% carcinoma were medullary. Thus, papillary carcinoma was more common among all solitary thyroid nodular malignancies. 

Author Biographies

Abdullah Al Mamun, General Hospital, Narayanganj

Department of ENT & Head-Neck Surgery, General Hospital, Narayanganj

Zahedul Alam, National Institute of ENT, Tejgaon, Dhaka

National Institute of ENT, Tejgaon, Dhaka

Mazharul Islam, Rangpur Medical College, Rangpur

Department of ENT & Head-Neck Surgery, Rangpur Medical College, Rangpur

Mashuque Mahamud, National Institute of ENT, Tejgaon, Dhaka

National Institute of ENT, Tejgaon, Dhaka

Mohammad Ashaduzzaman, Colonel Malek Medical College, Manikganj

Department of Hepatology, Colonel Malek Medical College, Manikganj

Md Shaiful Azam, Colonel Malek Medical College, Manikganj

Department of Paediatrics, Colonel Malek Medical College, Manikganj

G H M Shahidul Haque, Colonel Malek Medical College, Manikganj

Department of ENT & Head-Neck Surgery, Colonel Malek Medical College, Manikganj


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How to Cite

Mamun AA, Alam Z, Islam M, Mahamud M, Ashaduzzaman M, Azam MS, Haque GHMS. Clinicopathological Study of Solitary Thyroid Nodule. CMMCJ [Internet]. 2019 Jul. 31 [cited 2023 Jan. 28];2(02):18-25. Available from:



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