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Abstract

Hepatitis B virus (HBV) infection is a global public health problem. The need for non-invasive tools to assess liver fibrosis in chronic liver diseases has been largely advocated. This study aims to assess correlation and diagnostic accuracy between liver elasticity measured by fibroscan and liver fibrosis assessed by histology in patients with chronic hepatitis B. For the purpose 70 patients with chronic hepatitis B were selected. They underwent liver biopsy, LSM and complete histopathological examination including HAI and Knodell score. In histological examination stage -1 fibrosis was 78.6%, stage -3 was 20% and stage– 4 was 1.4%. In LSM staging, F1 fibrosis was 71.4%, F2 fibrosis was 4.3%, F3 fibrosis was18.6% and F4 fibrosis was 5.7%. The optimal cut off values in the study were 7.2, 10.5 and 18.2 kpa for the diagnosis of F-2, F-3 and F=4 respectively which was strongly correlated with fibrosis stage (r=.608, p=.000). This study showed that LSM is an accurate method for the diagnosis of fibrosis stage in patients with chronic hepatitis B and may be a useful tool in the management of these patients besides liver biopsy.

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Author Biographies

Mohammad Ashaduzzaman, Colonel Malek Medical College, Manikganj

Department of Hepatology, Colonel Malek Medical College, Manikganj, Bangladesh

Mamun Al Mahtab, Bangabandhu Sheikh Mujib Medical University

Department of Hepatology, BSMMU, Dhaka

Salimur Rahman, Bangabandhu Sheikh Mujib Medical University

Department of Hepatology, BSMMU, Dhaka, Bangladesh

Mohammad Aminul Hoque, Colonel Malek Medical College, Manikganj

Assistant Professor, Department of Gastroenterology, Colonel Malek Medical College, Manikganj

A K M Aminul Islam, Colonel Malek Medical College, Manikganj

Colonel Malek Medical College, Manikganj

Nur Faysal Ahmed, 300 Bed Hospital, Narayanganj

Department of Medicine, 300 Bed Hospital, Narayanganj

How to Cite
1.
Ashaduzzaman M, Mahtab MA, Rahman S, Hoque MA, Islam AKMA, Ahmed NF. Correlation Between Liver Elasticity Measured by Fibroscan and Liver Fibrosis Assessed by Histology in Patients with Chronic Hepatitis B. CMMCJ [Internet]. 2019 Jul. 31 [cited 2022 Aug. 13];2(02):8-13. Available from: https://cmmcj.org/index.php/cmmcj/article/view/22

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